NIPER Entrance Exam for M.Pharm Subjects

I need the NIPER Entrance Exam for M.Pharm Syllabus, will you please provide me the same??????

[Raman Vij]

Here I am sharing the NIPER Entrance Exam for M.Pharm Syllabus:

1. Inter and intramolecular interactions: Weak interactions in drug molecules; Chirality and drug action;
Covalent, ion, ion-dipole, hydrogen bonding, C-H hydrogen bonding, dihydrogen bonding, van der
Waals interactions and the associated energies.
2. Energy concept and its importance in drug action; First, second and third laws of thermodynamics
and the principles derived from these laws which are of significance to drug action; Free energy and
relationship between thermodynamics and statistics; Importance of chemical potential in drug action;
Thermodynamic cycle.
3. Statistical thermodynamics in predicting the structure of biomolecules and their interaction with drug
molecules; Macromolecular vs. micromolecular correlation using thermodynamics and statistical
thermodynamics.
4. Receptorology: Drug-receptor interactions, receptor theories and drug action; Occupancy theory, rate
theory, induced fit theory, macromolecular perturbation theory, activation-aggregation theory.
Topological and stereochemical consideration
5. Kinetics, enzyme kinetics in drug action. Do all molecules of an enzyme have same kinetics?
Mechanisms of enzyme catalysis; Electrostatic catalysis and desolvation; Covalent catalysis, acidbase
catalysis, strain / distortion in enzyme catalysis; Coenzyme catalysis; Example based on
hemoglobin; Theories of enzyme inhibition and inactivation; Enzyme activation of drugs-prodrugs.
6. Nucleic acids (NA) as targets for drug action; NA-interactive agents; Classes of drugs that interact
with nucleic acids; Intercalation, NA-alkylation, NA-strand breaking and their importance in drug
action.

Detailed syllabus is in the attachment, download it freely from here:

NIPER Entrance Exam for M.Pharm Syllabus