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Old 27th July 2015, 04:04 PM
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Default Re: Jamia Hamdard University Msc

Jamia Hamdard was established in the year 1989 and it is a university located in New Delhi, India .

It provides MSc Biochemistry course .

It is a four semester program, spread over a period of two years.

Eligibility

Candidates desirous of admission to the course must have:

i.Passed BSc in Biochemistry or equivalent examination in Biological Sciences with Biochemistry or Chemistry as one of the subjects with 55% marks in aggregate

ii. Appeared in the Entrance Test conducted by Jamia Hamdard
Jamia Hamdard University MSc Biochemistry syllabus
Course content
Credit Marks
SEMESTER EMESTER – I
Course I MFC 001: Foundation Course* 10 200
Course II MBC 101: Cell Biology 4 100
Course III MBC 102: Biomolecules 4 100
Course IV MBC 103: Bioenergetics and Intermediary Metabolism 4 100
Course V MBC 104: Molecular Biology 4 100
Course VI MBC 105: Lab Course-1 4 100
(Analytical and separation techniques)
30 700
SEMESTER EMESTER – II
Course VII MBC 201: Enzymes 4 100
Course VIII MBC 202: Metabolism 4 100
Course IX MBC 203: Gene expression 4 100
Course X MBC 204: Protein and Proteomics 4 100
Course XI MBC 205: Seminar and Report Writing 4 100
Course XII MBC 206: Lab Course-2 4 100
(Enzyme analysis and immobilization techniques)
24 600
SEMESTER EMESTER – III
Course XIII MBC 301: Genetic Engineering 4 100
Course XIV MBC 302: Clinical Biochemistry and Nutrition 4 100
Course XV MBC 303: Microbiology 4 100
Course XVI MBC 304: Immunology 4 100
Course XVII MBC 305: Dissertation-1 8 200
(Microbial and molecular biology techniques)
24 600
SEMESTER EMESTER – IV
Course XVIII MBC 401: Biotechnology and Nanotechnology 4 100
Course XIX MBC 402: Computational Biochemistry and Bioinformatics 4 100
Course XX MBC 403: Biochemical Techniques and Biostatistics 4 100
Course XXI MBC 404: Industrial Biochemistry 4 100
Course XXII MBC 405: Dissertation-2 8 200
(Protein isolation, purification and immunological techniques)
24 600
Credits redits in four semesters semesters: 102
Total marks marks: 2500
Each paper will be taught in 50 lectures, each of one-hour duration, except for the Foundation Course where the
number of lecturers will be 100. Foundation course will be coordinated by the Dean of the Faculty.
*Course content of the Foundation Course (MFC001) is provided in Annexure-1.
Semester I
Course II
Cell Biology
Paper code: MBC 101
Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam)
Cell is the unit of life and the site where the processes of life originate and occur. This paper is aimed at to
provide an insight into the organization, biochemistry and functions of the cell, and is expected to make
the student understand the biological sciences and explore the reactions and processes in living
organisms for the benefit of mankind.
Unit I: An overview of the cell and cell structure
Introduction to the cell, its chemical composition, molecular organization, origin and
evolution; prokaryotic and eukaryotic cells; cell theory and modern cell biology; cell
organelles; structure and function of endoplasmic reticulum, Golgi body, endosome,
lysosome, vacuole, peroxisome, ribosome, mitochondria, chloroplast, nucleus,
cytoskeleton, cell wall; subcellular fractionation; cytoplasm and cytosol; methods to study
the cell: principles of microscopy, centrifugation, tissue culture and flow cytometry.
Un Unit II: it Membrane biochemistry and function
iochemistry Membrane: chemical composition and its structural plan; membrane models; membrane
as a two dimensional fluid; factors affecting the membrane fluidity; phase transition;
membrane proteins; movement of small and large molecules across the cell membrane;
osmosis; diffusion; endocytosis; clathrin mediated endocytosis; phagocytosis; artificial
membranes.
Unit III: Major cell function functions
Cytoplasmic membrane or endomembrane system; secretion and transport of proteins to
various cell compartments; signal hypothesis; protein targeting to peroxisomes; packaging
of DNA into eukaryotic chromosome; nucleosomes and higher levels of organization;
nuclear pore complex; molecular trafficking; nucleolus and the synthesis of ribosome;
electric properties of membrane; patch clamp and voltage clamp techniques.
Unit IV: Signal transduction, cell cycle, cell death death, stem cell and regeneration
, Receptors and ligands; transduction of signal into the cell; G protein coupled receptors;
growth factors and receptor tyrosine kinase; second messengers; cell cycle and regulation;
cancer; characteristics of tumor cells; mechanism of transformation; angiogenesis; tumour
suppressor genes; cell signaling in development and differentiation; regulatory genes in the
development of Drosophila; stem cell; regeneration; autophagy and cell death.
Semester I
Course III
Biomolecules
Paper code: MBC 102
Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam)
Objective of this course is to introduce the student the structure and function of biomolecules, and
understand the chemical principles in life processes. Classification, disorders related to overproduction
and underproduction of hormones are also emphasized in this paper.
Unit I: Carbohydrates
Occurrence, classification, characteristics, structure and functions of monosaccharides,
disaccharides and polysaccharides; structure and conformation of sugars; monosaccharides:
stereoisomerism and optical isomerism; chemical reactions of the functional groups; sugar
derivatives; mucoploysaccharides; glycosaminoglycans; proteoglycans; glycoproteins;
glycobiology.
Unit II: Lipids
Classification and types of lipids; structure, nomenclature and properties of fatty acids;
glycosides; soaps and detergents; structure, classification, properties and functions of
phospholipids and sphingolipids; glycolipids; composition and biological role of
lipoproteins; structure and functions of steroids and prostaglandins; eicosanoids; vegetable
and fish oils.
Unit III: Amino acids, nucleotide nucleotides and water
s Structure, nomenclature, classification, acid-base behavior and chemical reactions of amino
acids; stereoisomerism and optical properties of amino acids; non-natural amino acids;
structure and functions of nucleotides and alarmones; water and its physicochemical
properties.
Unit IV: Hormones
General characteristics, classification, chemistry, functions, mechanisms and abnormalities
of thyroid, parathyroid, adrenal, pancreatic, gastric and reproductive hormones;
hypothalamus and pituitary; detection of hormones; hormone replacement therapy; plant
hormones; pheromones.
Semester I
Course IV
Bioenergetics and Intermediary Metabolism
Paper code: MBC 103
Credits: 4, Lectures: 50, Maximum marks: 100 (Internal Assessment +75 Semester Exam)
This course deals with the introduction to the laws of thermodynamics and their significance in
biological systems, the concept of metabolism, characteristics of metabolic pathways and strategies used
to study these pathways. This is followed by a detailed overview of various pathways involved in
carbohydrate metabolism with their significance and regulation. The course also focuses on some
important plant-specific metabolic pathways with relevant details.
Unit I: Bioenergetics
Bioenergetics: concepts, laws of thermodynamics, free energy, standard free energy;
determination of ∆G for a reaction; equilibrium constant and standard free energy change;
biological oxidation-reduction reactions; redox potential; relation between standard
reduction potentials and free energy change; ATP as universal energy currency in biological
systems; role of NADH and NADPH in metabolism; strategies to study metabolic
pathways: inhibitors and radioisotope techniques.
Unit II: Carbohydrates metabolism
Digestion and absorption of carbohydrates; glycolysis; citric acid cycle; pentose phosphate
pathway; gluconeogenesis; glucuronate pathway and their regulation; metabolism of
disaccharides; biosynthesis of oligosaccharides and glycoproteins; glycogen metabolism and
its regulation; glycogen storage diseases; regulation of carbohydrate metabolism; metabolic
adaptation in starvation and diabetes mellitus.
Unit III: Phosphorylation
Electron transport chain; electron carriers and their organization; respiratory complexes;
oxidative phosphorylation; sites of phosphorylation; P/O ratio; energetics of oxidative
phosphorylation; inhibitors and uncouplers of oxidative phosphorylation; microsomal
electron transport chain; reactions that generate and utilize ATP in the cell; substrate level
phosphorylation; high-energy compounds in biological systems.
Unit IV: Plant metabolism
Plant-specific metabolic pathways; photosynthesis and carbon fixation; cyclic and noncyclic
electron transport; C3, C4, and CAM pathways; photorespiration; fixation of atmospheric
nitrogen and properties of nitrogenase complex; secondary metabolites and their
significance; metabolism of isoprenoids; glyoxylate cycle; role of vacuole in plant
metabolism.
Semester I
Course V
Molecular Biology
Paper code: MBC 104
Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam)
This course has been designed to give insight into the structure and function of nucleic acids, basic
principles of genetics, molecular evolution, mechanism of DNA replication, transcription, molecular basis
of mutations and site directed mutagenesis.
Unit I: Nucleic acids
DNA as genetic material; primary, secondary and three-dimensional structures of DNA;
supercoiling; forms of DNA; polytene and lampbrush chromosomes; properties of DNA
in solution; denaturation and renaturation; reassociation reactions; COT curves; types of
RNAs and their primary and secondary structure; role of RNA; unusual bases in RNA.
Unit II: Molecular evolution
Mendelian principles: dominance, segregation, independent assortment, pleiotropy;
genome imprinting; molecular evolution: separation, natural selection, and evolution of
proteins and nucleotide sequences; allelic frequency; calculation of allelic frequency;
molecular clocks; evolution by gene duplication and exon shuffling; deleterious genes;
eugenics; gene frequencies and conservation of gene frequencies; convergent evolution.
Unit I III: I: Replication
Replication of DNA and synthesis of RNA; central dogma of molecular biology; DNA and
RNA polymerases and other enzymes involved in replication; mechanisms of replication;
inhibitors of transcription; proof reading function and fidelity of DNA replication; possible
modes of DNA replication; theta model and rolling circle model of DNA replication;
replication of DNA in eukaryotes; role of methylation; replication of viral RNA; reverse
transcriptase.
Unit IV IV: Transcription
Prokaryotic and eukaryotic gene structure; transposable elements in bacteria; mobile
elements in eukaryotes; regulatory region and transcriptional unit of gene; posttranscriptional
processing of RNA: splicing, cap addition and polyadenylation;
polynucleotide phosphorylase; classification and molecular basis of mutation; Ames test
and other testing systems; repair mechanism in prokaryotes and eukaryotes; site directed
mutagenesis.
Course VI
Lab Course -1
Paper code: MBC 105
Credits: 4, Hours: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam)
Exercises in the lab course are primarily aimed at providing hands-on training to the student on various
analytical and separation techniques, and introduce him to the methods of studying biological molecules.
Teacher supervising the lab will be explaining the principle, theory and instrumentation of the technique
to be used before starting the practical exercise.
Analy Analytical tical and separation techniques
1. Qualitative analysis of carbohydrates, lipids, amino acids, and proteins from biological sample
2. Quantitative (spectrophotometric) analysis of glucose, cholesterol, protein, and nucleic acid
3. Chromatographic separation of sugars, fatty acids, and amino acids by paper and thin layer
chromatography
4. GC, HPLC, HPTLC (Demonstration only)
5. Isolation of polysaccharide (starch or glycogen) from the biological material
6. Isolation of casein from milk
7. Digestion of casein and determination of phosphate in the digest
8. Extraction of lipid/oil from the plant material and determination of its saponification and iodine
number
9. Centrifugation technique: subcellular fractionation, and isolation of nuclei and mitochondria from
the tissue
10. Immobilization of cell: RBC/yeast
11. Nanodrop (Demonstration only)
Semester II
Course VII
Enzymes
Paper code: MBC 201
Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam)
This course is meant to give student an in-depth knowledge of enzyme, their classification, catalysis and
kinetics, as well as to give an account of the catalytic mechanisms and immobilized enzymes.
Unit I: Enzymes – Introduction and classification
Enzymes as biological catalysts: characteristics, nomenclature and classification; enzyme
assay and enzyme activity; enzyme units; coenzymes: structure and function; factors
affecting initial velocity of enzyme catalyzed reactions; multifunctional enzymes and
multienzyme complexes; isoenzymes and their analysis; ribozyme; catalytic antibodies; nonenzymatic
biochemical reactions.
Unit II: Enzyme kinetics and enzyme inhibition
Kinetics of enzyme catalyzed reactions; steady-state hypothesis and derivation of Michaelis-
Menten equation; significance of Km and Vmax and their determination using different plots;
double reciprocal plot; enzyme inhibition: competitive, noncompetitive, and uncompetitive
inhibition; excess substrate inhibition; enzyme kinetics in the presence of inhibitors;
determination of Ki; enzyme catalyzed reactions involving two substrates.
Unit III: Catalytic mechanisms
Catalytic efficiency and factors associated with catalytic efficiency: proximity, orientation,
distortion and strain; catalytic mechanisms: acid-base, covalent, metal ion and electrostatic
catalysis; active site mapping of enzymes; experimental approaches to the determination of
enzyme mechanisms; mechanism of action of lysozyme and serine proteases.
Unit IV: Regulation of enzyme activity and i immobilized enzymes
mmobilized Mechanisms to control the enzyme activity; allosteric enzymes and their kinetics; Hill and
scatchard plots; models of allosteric regulation; enzyme immobilization: methods, kinetics
and applications; enzyme turnover and its significance; convergent and divergent evolution
of enzymes.
Semester II
Course VIII
Metabolism
Paper code: MBC 202
Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam)
The paper is in continuation to the paper on metabolism in the first semester where the metabolism of
lipids, amino acids and nucleotides were discussed with significant detail. The paper gives an idea to the
student about how biomolecules other than carbohydrates are metabolized. Lipids, amino acids and
nucleotides have been individually addressed. The last unit deals with the non-enzymatic reactions in the
body and their significance. Beside this, toxicity of various pollutants and their impact on metabolism in
particular and organism as a whole have also been focused.
Unit I: Lipid metabolism
Dietary lipids: digestion, absorption and metabolism; main and alternative pathways of fatty
acid oxidation; oxidation of odd carbon number and unsaturated fatty acids; biosynthesis of
saturated and unsaturated fatty acids; metabolism of triacylglycerols, phospholipids,
glycolipids, sphingolipids and cholesterol; formation of ketone bodies and their oxidation;
leptons; fatty acid biosynthesis in plants; lipoprotein metabolism.
Unit II: Amino acid m metabolism etabolism
Digestion of proteins and absorption of amino acids; general reactions in the degradation
of amino acids; deamination and transamination reactions; urea cycle; fate of the carbon
skeleton of amino acids; essential and nonessential amino acids; biosynthesis of individual
amino acids; regulation of amino acid biosynthesis; inborn errors of amino acid
metabolism.
Unit III: Nucleic acid metabolism
Degradation of nucleic acids; deoxyribonucleases and ribonucleases; biosynthesis and
degradation of purine and pyrimidine nucleotides; regulation of purine and pyrimidine
nucleotide metabolism; biosynthesis of deoxyribonucleotides; interconversion of
nucleotides; inborn errors of nucleotide metabolism; biosynthesis of nucleotide
coenzymes; metabolism of porphyrins.
Unit IV: Xenobiotic metab metaboli li lism sm and environmental biochemistry
Metabolism and toxicity assessment of xenobiotics; environment and pollution; pollutants
and cellular metabolism; biotransformation; drug metabolizing enzymes; eutrophication;
biomagnifications; biochemical effects of As, Cd, Pb, Hg, Co, NOx, SOx, O3, cyanide,
hydrocarbons, particulate matter, pesticides and other common pollutants; green house
effect; global warming and consequences on plant and animal metabolism.
Contact Details :
Jamia Hamdard University
Mehrauli - Badarpur Rd, Hamdard Nagar, New Delhi, Delhi 110062
011 2605 9688
For the syllabus , here is the attachment;
Attached Files
File Type: pdf Jamia Hamdard University MSc Biochemistry syllabus.pdf (303.5 KB, 44 views)
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