Brain Dce-Mri

Today I got a question in my Exam that “ How to Perform Dynamic Contrast Enhanced (DCE) Magnetic resonance imaging (MRI) “ ? I left this question because I didn’t know about it . Would you please provide me all the details related to it so I will get some idea about it ??

Can you provide me the details of DCE-MRI (Dynamic Contrast-Enhanced Magnetic Resonance Imaging): fundamentals and application to the evaluation of the peripheral perfusion?

[sumit]

Dynamic Magnetic Resonance Imaging (MRI) has been applied for over a decade to extract functional information regarding the peripheral vascular system (1-4).

2 frequently used techniques- Blood Oxygen Level-Dependent (BOLD) MRI and Arterial Spin Labelling (ASL) are limited to the measurement of energy consumption and perfusion but are unable to ascertain information regarding vessel permeability or volume fractions (5-8).

DCE-MRI however, provides the possibility for multiple and quantifiable parameters pertaining to tissue perfusion and microvascular status. Since its initial presentation, the approach has mainly been applied in studies of the myocardium, the brain and oncological research. Lately, DCE-MRI has also been adopted to examine the peripheral vascular and muscular system.

The first part of this review will elucidate the fundamentals of data acquisition and interpretation of DCE-MRI, two areas that often remain baffling to the clinical and investigating physician because of their complexity. Basic fundamentals will be explained including the physical and physiological concepts behind DCE-MRI.

The second part will discuss developments and exciting perspectives of DCE-MRI regarding the assessment of perfusion in the extremities. Emerging clinical applications of DCE-MRI will be reviewed with a special focus on investigation of physiology and pathophysiology of the microvascular and vascular systems of the extremities.