Jamia Hamdard University Msc I want to take admission in MSc Biochemistry course offered at Jamia Hamdard University . Will you please provide the syllabus for an idea ? |
Re: Jamia Hamdard University Msc 1 Attachment(s) Jamia Hamdard was established in the year 1989 and it is a university located in New Delhi, India . It provides MSc Biochemistry course . It is a four semester program, spread over a period of two years. Eligibility Candidates desirous of admission to the course must have: i.Passed BSc in Biochemistry or equivalent examination in Biological Sciences with Biochemistry or Chemistry as one of the subjects with 55% marks in aggregate ii. Appeared in the Entrance Test conducted by Jamia Hamdard Jamia Hamdard University MSc Biochemistry syllabus Course content Credit Marks SEMESTER EMESTER – I Course I MFC 001: Foundation Course* 10 200 Course II MBC 101: Cell Biology 4 100 Course III MBC 102: Biomolecules 4 100 Course IV MBC 103: Bioenergetics and Intermediary Metabolism 4 100 Course V MBC 104: Molecular Biology 4 100 Course VI MBC 105: Lab Course-1 4 100 (Analytical and separation techniques) 30 700 SEMESTER EMESTER – II Course VII MBC 201: Enzymes 4 100 Course VIII MBC 202: Metabolism 4 100 Course IX MBC 203: Gene expression 4 100 Course X MBC 204: Protein and Proteomics 4 100 Course XI MBC 205: Seminar and Report Writing 4 100 Course XII MBC 206: Lab Course-2 4 100 (Enzyme analysis and immobilization techniques) 24 600 SEMESTER EMESTER – III Course XIII MBC 301: Genetic Engineering 4 100 Course XIV MBC 302: Clinical Biochemistry and Nutrition 4 100 Course XV MBC 303: Microbiology 4 100 Course XVI MBC 304: Immunology 4 100 Course XVII MBC 305: Dissertation-1 8 200 (Microbial and molecular biology techniques) 24 600 SEMESTER EMESTER – IV Course XVIII MBC 401: Biotechnology and Nanotechnology 4 100 Course XIX MBC 402: Computational Biochemistry and Bioinformatics 4 100 Course XX MBC 403: Biochemical Techniques and Biostatistics 4 100 Course XXI MBC 404: Industrial Biochemistry 4 100 Course XXII MBC 405: Dissertation-2 8 200 (Protein isolation, purification and immunological techniques) 24 600 Credits redits in four semesters semesters: 102 Total marks marks: 2500 Each paper will be taught in 50 lectures, each of one-hour duration, except for the Foundation Course where the number of lecturers will be 100. Foundation course will be coordinated by the Dean of the Faculty. *Course content of the Foundation Course (MFC001) is provided in Annexure-1. Semester I Course II Cell Biology Paper code: MBC 101 Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam) Cell is the unit of life and the site where the processes of life originate and occur. This paper is aimed at to provide an insight into the organization, biochemistry and functions of the cell, and is expected to make the student understand the biological sciences and explore the reactions and processes in living organisms for the benefit of mankind. Unit I: An overview of the cell and cell structure Introduction to the cell, its chemical composition, molecular organization, origin and evolution; prokaryotic and eukaryotic cells; cell theory and modern cell biology; cell organelles; structure and function of endoplasmic reticulum, Golgi body, endosome, lysosome, vacuole, peroxisome, ribosome, mitochondria, chloroplast, nucleus, cytoskeleton, cell wall; subcellular fractionation; cytoplasm and cytosol; methods to study the cell: principles of microscopy, centrifugation, tissue culture and flow cytometry. Un Unit II: it Membrane biochemistry and function iochemistry Membrane: chemical composition and its structural plan; membrane models; membrane as a two dimensional fluid; factors affecting the membrane fluidity; phase transition; membrane proteins; movement of small and large molecules across the cell membrane; osmosis; diffusion; endocytosis; clathrin mediated endocytosis; phagocytosis; artificial membranes. Unit III: Major cell function functions Cytoplasmic membrane or endomembrane system; secretion and transport of proteins to various cell compartments; signal hypothesis; protein targeting to peroxisomes; packaging of DNA into eukaryotic chromosome; nucleosomes and higher levels of organization; nuclear pore complex; molecular trafficking; nucleolus and the synthesis of ribosome; electric properties of membrane; patch clamp and voltage clamp techniques. Unit IV: Signal transduction, cell cycle, cell death death, stem cell and regeneration , Receptors and ligands; transduction of signal into the cell; G protein coupled receptors; growth factors and receptor tyrosine kinase; second messengers; cell cycle and regulation; cancer; characteristics of tumor cells; mechanism of transformation; angiogenesis; tumour suppressor genes; cell signaling in development and differentiation; regulatory genes in the development of Drosophila; stem cell; regeneration; autophagy and cell death. Semester I Course III Biomolecules Paper code: MBC 102 Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam) Objective of this course is to introduce the student the structure and function of biomolecules, and understand the chemical principles in life processes. Classification, disorders related to overproduction and underproduction of hormones are also emphasized in this paper. Unit I: Carbohydrates Occurrence, classification, characteristics, structure and functions of monosaccharides, disaccharides and polysaccharides; structure and conformation of sugars; monosaccharides: stereoisomerism and optical isomerism; chemical reactions of the functional groups; sugar derivatives; mucoploysaccharides; glycosaminoglycans; proteoglycans; glycoproteins; glycobiology. Unit II: Lipids Classification and types of lipids; structure, nomenclature and properties of fatty acids; glycosides; soaps and detergents; structure, classification, properties and functions of phospholipids and sphingolipids; glycolipids; composition and biological role of lipoproteins; structure and functions of steroids and prostaglandins; eicosanoids; vegetable and fish oils. Unit III: Amino acids, nucleotide nucleotides and water s Structure, nomenclature, classification, acid-base behavior and chemical reactions of amino acids; stereoisomerism and optical properties of amino acids; non-natural amino acids; structure and functions of nucleotides and alarmones; water and its physicochemical properties. Unit IV: Hormones General characteristics, classification, chemistry, functions, mechanisms and abnormalities of thyroid, parathyroid, adrenal, pancreatic, gastric and reproductive hormones; hypothalamus and pituitary; detection of hormones; hormone replacement therapy; plant hormones; pheromones. Semester I Course IV Bioenergetics and Intermediary Metabolism Paper code: MBC 103 Credits: 4, Lectures: 50, Maximum marks: 100 (Internal Assessment +75 Semester Exam) This course deals with the introduction to the laws of thermodynamics and their significance in biological systems, the concept of metabolism, characteristics of metabolic pathways and strategies used to study these pathways. This is followed by a detailed overview of various pathways involved in carbohydrate metabolism with their significance and regulation. The course also focuses on some important plant-specific metabolic pathways with relevant details. Unit I: Bioenergetics Bioenergetics: concepts, laws of thermodynamics, free energy, standard free energy; determination of ∆G for a reaction; equilibrium constant and standard free energy change; biological oxidation-reduction reactions; redox potential; relation between standard reduction potentials and free energy change; ATP as universal energy currency in biological systems; role of NADH and NADPH in metabolism; strategies to study metabolic pathways: inhibitors and radioisotope techniques. Unit II: Carbohydrates metabolism Digestion and absorption of carbohydrates; glycolysis; citric acid cycle; pentose phosphate pathway; gluconeogenesis; glucuronate pathway and their regulation; metabolism of disaccharides; biosynthesis of oligosaccharides and glycoproteins; glycogen metabolism and its regulation; glycogen storage diseases; regulation of carbohydrate metabolism; metabolic adaptation in starvation and diabetes mellitus. Unit III: Phosphorylation Electron transport chain; electron carriers and their organization; respiratory complexes; oxidative phosphorylation; sites of phosphorylation; P/O ratio; energetics of oxidative phosphorylation; inhibitors and uncouplers of oxidative phosphorylation; microsomal electron transport chain; reactions that generate and utilize ATP in the cell; substrate level phosphorylation; high-energy compounds in biological systems. Unit IV: Plant metabolism Plant-specific metabolic pathways; photosynthesis and carbon fixation; cyclic and noncyclic electron transport; C3, C4, and CAM pathways; photorespiration; fixation of atmospheric nitrogen and properties of nitrogenase complex; secondary metabolites and their significance; metabolism of isoprenoids; glyoxylate cycle; role of vacuole in plant metabolism. Semester I Course V Molecular Biology Paper code: MBC 104 Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam) This course has been designed to give insight into the structure and function of nucleic acids, basic principles of genetics, molecular evolution, mechanism of DNA replication, transcription, molecular basis of mutations and site directed mutagenesis. Unit I: Nucleic acids DNA as genetic material; primary, secondary and three-dimensional structures of DNA; supercoiling; forms of DNA; polytene and lampbrush chromosomes; properties of DNA in solution; denaturation and renaturation; reassociation reactions; COT curves; types of RNAs and their primary and secondary structure; role of RNA; unusual bases in RNA. Unit II: Molecular evolution Mendelian principles: dominance, segregation, independent assortment, pleiotropy; genome imprinting; molecular evolution: separation, natural selection, and evolution of proteins and nucleotide sequences; allelic frequency; calculation of allelic frequency; molecular clocks; evolution by gene duplication and exon shuffling; deleterious genes; eugenics; gene frequencies and conservation of gene frequencies; convergent evolution. Unit I III: I: Replication Replication of DNA and synthesis of RNA; central dogma of molecular biology; DNA and RNA polymerases and other enzymes involved in replication; mechanisms of replication; inhibitors of transcription; proof reading function and fidelity of DNA replication; possible modes of DNA replication; theta model and rolling circle model of DNA replication; replication of DNA in eukaryotes; role of methylation; replication of viral RNA; reverse transcriptase. Unit IV IV: Transcription Prokaryotic and eukaryotic gene structure; transposable elements in bacteria; mobile elements in eukaryotes; regulatory region and transcriptional unit of gene; posttranscriptional processing of RNA: splicing, cap addition and polyadenylation; polynucleotide phosphorylase; classification and molecular basis of mutation; Ames test and other testing systems; repair mechanism in prokaryotes and eukaryotes; site directed mutagenesis. Course VI Lab Course -1 Paper code: MBC 105 Credits: 4, Hours: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam) Exercises in the lab course are primarily aimed at providing hands-on training to the student on various analytical and separation techniques, and introduce him to the methods of studying biological molecules. Teacher supervising the lab will be explaining the principle, theory and instrumentation of the technique to be used before starting the practical exercise. Analy Analytical tical and separation techniques 1. Qualitative analysis of carbohydrates, lipids, amino acids, and proteins from biological sample 2. Quantitative (spectrophotometric) analysis of glucose, cholesterol, protein, and nucleic acid 3. Chromatographic separation of sugars, fatty acids, and amino acids by paper and thin layer chromatography 4. GC, HPLC, HPTLC (Demonstration only) 5. Isolation of polysaccharide (starch or glycogen) from the biological material 6. Isolation of casein from milk 7. Digestion of casein and determination of phosphate in the digest 8. Extraction of lipid/oil from the plant material and determination of its saponification and iodine number 9. Centrifugation technique: subcellular fractionation, and isolation of nuclei and mitochondria from the tissue 10. Immobilization of cell: RBC/yeast 11. Nanodrop (Demonstration only) Semester II Course VII Enzymes Paper code: MBC 201 Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam) This course is meant to give student an in-depth knowledge of enzyme, their classification, catalysis and kinetics, as well as to give an account of the catalytic mechanisms and immobilized enzymes. Unit I: Enzymes – Introduction and classification Enzymes as biological catalysts: characteristics, nomenclature and classification; enzyme assay and enzyme activity; enzyme units; coenzymes: structure and function; factors affecting initial velocity of enzyme catalyzed reactions; multifunctional enzymes and multienzyme complexes; isoenzymes and their analysis; ribozyme; catalytic antibodies; nonenzymatic biochemical reactions. Unit II: Enzyme kinetics and enzyme inhibition Kinetics of enzyme catalyzed reactions; steady-state hypothesis and derivation of Michaelis- Menten equation; significance of Km and Vmax and their determination using different plots; double reciprocal plot; enzyme inhibition: competitive, noncompetitive, and uncompetitive inhibition; excess substrate inhibition; enzyme kinetics in the presence of inhibitors; determination of Ki; enzyme catalyzed reactions involving two substrates. Unit III: Catalytic mechanisms Catalytic efficiency and factors associated with catalytic efficiency: proximity, orientation, distortion and strain; catalytic mechanisms: acid-base, covalent, metal ion and electrostatic catalysis; active site mapping of enzymes; experimental approaches to the determination of enzyme mechanisms; mechanism of action of lysozyme and serine proteases. Unit IV: Regulation of enzyme activity and i immobilized enzymes mmobilized Mechanisms to control the enzyme activity; allosteric enzymes and their kinetics; Hill and scatchard plots; models of allosteric regulation; enzyme immobilization: methods, kinetics and applications; enzyme turnover and its significance; convergent and divergent evolution of enzymes. Semester II Course VIII Metabolism Paper code: MBC 202 Credits: 4, Lectures: 50, Maximum marks: 100 (25 Internal Assessment +75 Semester Exam) The paper is in continuation to the paper on metabolism in the first semester where the metabolism of lipids, amino acids and nucleotides were discussed with significant detail. The paper gives an idea to the student about how biomolecules other than carbohydrates are metabolized. Lipids, amino acids and nucleotides have been individually addressed. The last unit deals with the non-enzymatic reactions in the body and their significance. Beside this, toxicity of various pollutants and their impact on metabolism in particular and organism as a whole have also been focused. Unit I: Lipid metabolism Dietary lipids: digestion, absorption and metabolism; main and alternative pathways of fatty acid oxidation; oxidation of odd carbon number and unsaturated fatty acids; biosynthesis of saturated and unsaturated fatty acids; metabolism of triacylglycerols, phospholipids, glycolipids, sphingolipids and cholesterol; formation of ketone bodies and their oxidation; leptons; fatty acid biosynthesis in plants; lipoprotein metabolism. Unit II: Amino acid m metabolism etabolism Digestion of proteins and absorption of amino acids; general reactions in the degradation of amino acids; deamination and transamination reactions; urea cycle; fate of the carbon skeleton of amino acids; essential and nonessential amino acids; biosynthesis of individual amino acids; regulation of amino acid biosynthesis; inborn errors of amino acid metabolism. Unit III: Nucleic acid metabolism Degradation of nucleic acids; deoxyribonucleases and ribonucleases; biosynthesis and degradation of purine and pyrimidine nucleotides; regulation of purine and pyrimidine nucleotide metabolism; biosynthesis of deoxyribonucleotides; interconversion of nucleotides; inborn errors of nucleotide metabolism; biosynthesis of nucleotide coenzymes; metabolism of porphyrins. Unit IV: Xenobiotic metab metaboli li lism sm and environmental biochemistry Metabolism and toxicity assessment of xenobiotics; environment and pollution; pollutants and cellular metabolism; biotransformation; drug metabolizing enzymes; eutrophication; biomagnifications; biochemical effects of As, Cd, Pb, Hg, Co, NOx, SOx, O3, cyanide, hydrocarbons, particulate matter, pesticides and other common pollutants; green house effect; global warming and consequences on plant and animal metabolism. Contact Details : Jamia Hamdard University Mehrauli - Badarpur Rd, Hamdard Nagar, New Delhi, Delhi 110062 011 2605 9688 For the syllabus , here is the attachment; |
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