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23rd April 2020, 03:34 PM
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Re: GATE question papers of Pharmacy subject

GATE question papers of Pharmacy

Q.1 Quinoline alkaloids are biosynthesized via which one of the following pathways?
(A) Shikimic acid - tyrosine (B) Shikimic acid - tryptophan (C) Shikimic acid -
cathinone D) Shikimic acid - phenylalanine
Answer: B
Q.2 Khellin is an active constituent of which one of the following plants?
(A) Prunus serona B) Tribulus terrestis (C) Ammi visnaga D) Vanilla planifolia
Answer: C
Q.3 Which one of the following compounds is useful for the stimulation of cell division
and release of lateral bud dormancy?
(A) Zeatin (B) 2,4-Dichlorophenoxyacetic acid (C) Indoleacetic acid (D) Picloram
Answer: A
Q.4 A powdered drug has the following microscopic characters:
Anther cells, arenchyma, pollen grains, phloem fibers, volatile oil cells and stone cells. The
powder is obtained from which of the followings?
(A) Clove bud powder (B) Clove bud powder with stalk (C) Mother Clove (D)
None of the above
Answer: B
Q.5 Which of the following ergot alkaloids is water soluble and shows blue fluorescence?
(A) Ergosine (B) Ergotamine (C) Ergocristine (D) Ergometrine
Answer: D
Q.6 Goldbeater's skin test is used to detect the presence of which one of the following
classes of compounds?
(A) Tannins (B) Steroids (C) Glycerides (D) Resins
Answer: A
Q.7 Phenylethylisoquinoline is the precursor of which of the following alkaloids?
(A) Colchicine (B) Papaverine (C) Emetine (D) Cephaline
Answer: A
Q.8 Arrange the following fatty acids in decreasing order of their unsaturation (highest
to lowest):
[P] Stearic [Q] Oleic acid [R] Linolenic acid [S] Linoleic acid
(A) P>Q>R>S (B) S>R>P>Q (C) R>S>Q>P (D) Q>P>R>S
Answer: C
Q.9 Each Of the following options lists a phytoconstituent, its phytochemical grouping,
pharmacological activity and corresponding semisynthetic analogue. Find a
MISMATCHING option.
(A) Podophyllotoxin, lignan, anticancer, etoposide
(B) Sennoside, anthraquinone, laxative, sinigrin
(C) Atropine, alkaloid, anticholinergic, homatropine
(D) THC. terpenophenolic, psychoactive, nabilone
Answer: B
Q.10 Which of the following mechanisms is NOT related to platelet aggregation inhibitory
action?
(A) ADP receptor antagonism (B) Glycoprotein IIb/IIIa receptor antagonism (C)
Phosphodiesterase inhibition (D) Prostacvclin inhibition
Answer: C
Q.11 Which of the following species is being inactivated by the enzyme Dipeptidyl
peptidase-4?
(A) Oxytocin (B) Vasopressin (C) Incretin (D) Glucagon
Answer: D
Q.12 Two genetic types of Cannabis i.e. drug type and Hemp type are cultivated.
[P] Drug type cannabis is rich in (-)A-trans-tetrahydrocannabinol .
[Q] Hemp type cannabis is rich in cannabidiol
[R] Drug type cannabis is rich in cannabidiol -
[S] Hemp type cannabis contains elongated bast fibres
Which one of the given statements is correct?
(A) P is true, Q is true, R is true, S is true
(B) P is true, Q is false, R is false, S is true
(C) P is true, Q is true, R is false, S is true
(D) P is false, Q is false, R is true, S is false
Answer: C
Q.13 Inhibition/induction of which of the following Cytochrome P450enzyme system is
most likely to be involved in important drug-druginteractions?
(A) CYP3A4 (B) CYP2D6 (C) CYP2C9 (D) CYP1A2
Answer: A
Q.14 Choose the correct statement about the given four diseases?
[P] Cardiomyopathy ],Q] Rheumatoid arthritis
[R] Myasthenia gravis [S] Ulcerative colitis
(A) Q & S are autoimmune disorders
(B) P & Q are autoimmune disorders
(C) P & R are not autoimmune disorders
(D) R & S are not autoimmune disorders
Answer: A
Q.15 Most of the emergency contraceptives have one of the following active ingredients?
(A) Estradiol (B) Norethindron (C) Misoprostol (D) Levonorgesterel
Answer: D
Q.16 Antiretroviral Raltegravir is unique, because of which of its following actions?
(A) Integrase inhibition (C) CCR5 Co-receptor antagonism (C) Fusion inhibition
(D) Reverse transcriptase inhibition
Answer: A
Q.17 Which one of the followings is NOT an example of G-protein coupled receptor?
(A) Muscarinic cholinergic receptor (B) Alpha adrenoceptor (C) Nicotinic cholinergic
receptor (D) Beta adrenoceptor
Answer: C
Q.18 Which of the following statements is FALSE for artemisinin?
(A) It is a sesquiterpene lactone endoperoxide
(B) It is a drug of choice in prophylaxis of malaria
(C) It does not cure relapsing malaria
(D) It is useful in treatment of cerebral falciparum malaria
Answer: B
Q.19 Which of the following antibiotics produces concentration dependent bactericidal
action and also possesses post-antibiotic effect?
(A) Ceftazidime (B) Azithromycin (C) Amikacin (D) Piperacillin
Answer: C
Q.20 What is chemotaxis?
(A) Toxicity of chemicals
(B) Taxonomy of chemicals
(C) Inhibition of Inflammation
.(D) Movement of leucocytes in inflammation
Answer: D
Q.21 Which of the followings used in the treatment of rheumatoid arthritis is NOT a
biologic response modifier?
(A) Anakinra (B) Leflunomide (C) Etanercept (D) Infliximab
Answer: B
Q.22 Which of the followings is a noncompetitive inhibitor of the enzyme reverse
transcriptase in HIV?
(A) Lamivudine (B) Nevirapine (C) Abacavir (D) Tenofovir
Answer: B
Q.23 Which one of the followings is a beta lactamase inhibitor?
(A) Penicillanic acid (B) Embonic acid
(C) Cephalosporanic acid (D) Clavulanic acid
Answer: D
Q.24 Neural tube defects may occur by which one of the following anti-seizure drugs?
(A) Ethosuximide (B) Vigabatrin (C) Valproic acid (D) Primidone
Answer: C
Q.25 Which one of the following drying methods is commonly used in pharma industry
for drjing of soft shell capsules?
(A) Truck drying (B) Fluid bed drying
(C) Vacuum drying (D) Microwave drying
Answer: C
Q.26 If C is the concentration of dissolved drug and Cs is the saturation concentration. In
which case the sink conditions are said to be maintained?
(A) C < 20% of Cs (B) C > 20% of Cs (C) C < 10% of Cs (D) C >10% of Cs
Answer: C
Q.27 All of the followings are indications for use of ACE inhibitors EXCEPT for one.
Identify that.
(A) Hypertension (B) Myocardial infarction
(C) Left ventricular dysfunction (D) Pheochromocytoma
Answer: D
Q.28 Which water is used for hand washing in a change room
of pharmaceutical manufacturing plant?
(A) Potable water (B) Purified water
(C) Disinfectant water (D) Soap water
Answer: A
Q.29 Which one of the followings does NOT afford a macromolecular inclusion
compound?
(A) Zeolites (B) Dextrins (C) Silica gels (D) Cyclodextrins
Answer: C
Q.30 Which condition does not apply as per Indian law while conducting
single dose bioavailability study of an immediate release product?
(A)Sampling period should be atleast three t1/2 ei
(B)Sampling should represent pre-exposure, peak exposure and post-exposure phases
(C)There should be atleast four sampling points during elimination phase
(D)Sampling should be continued till measured AUC is atleast equal to 80% of AUC
Answer: C
Q.31 Which of the following isothem are produced when the heat of condensation of
successive layers is more than the heat of adsorption of first layer?
(A) Type III and IV
(B) Type II and V
(C) Type I and III
(D) Type III and V
Answer: D
Q.32 The minimal effective flow rate of air in Luminar Flow hood should be not less than
how many cubic feet per minute?
(A) 10 (B) 50 (C) 100 (D) 1000
Answer: C
Q.33 Which of the following pumps is used in handling of corrosive liquids?
(A) Turbine pump (B) Volute Pump (C) Air binding pump (D) Baltic pump
Answer: D
Q.34 Convert 90% v/v alcohol to Proof strength. Choose the correct answer.
(A) 57.77° under proof (B) 57.77° over proof
(C) 47.41° over proof (D) 47.41° under proof
Answer: B
Q.35 What is the Heat of vaporization of water at 100:
(A) 2790 cal/ mole B> 7290 cal / mole
(C) 7920 cal/mole (D) 9720 cal/mole
Answer: D
Q.36 Which of the followings act as a non-ionic emulsifying agent?
(A) Triethanolamine oleate
(B) Polyoxyethylene sorbitan monooleate
(C) N-Cetyl-N-ethylmorpholinium ethosulfate
(D) Dioctyl sulphosuccinate
Answer: B
Q.37 Which of the following Schedules include shelf life of drugs?
(A) Schedule F (B) Schedule M (C) Schedule G (D) Schedule P
Answer: D
Q.38 By addition of which of the followings the shells of soft gelatin capsules may be
made elastic?
(A) Polyethylene glycol (B) Sorbitol
(C) Propylene glycol (D) Dibutyl phthalate
Answer: B
Q.39 Department of Transport Test (DOT) is performed for which of the followings?
(A) Strip packing (B) Aerosols
(C) Injection packing (D) Glass containers
Answer: B
Q.40 How many mL of 50% (w/v) dextrose solution and how many mL of 5% (w/v)
dextrose solution are required to prepare 4500 mL of a 10% (w/v) solution?
(A) 500 mL of 50% and 4000 mL of 5%
(B) 1000 mL of 50% and 3500 mL of 5%
(C) 4000 mL of 50% and 500 mL of 5%
(D) 1500 mL of 50% and 3000 mL of 5%
Answer: A
Q.41 P-Glycoprotein pump is responsible for which one of the followings?
(A) Transporting the drugs from the enterocytes into the gut lumen
(B) Transporting the drugs from gut lumen into enterocytes
(C) Transporting the drugs from oral mucosa into blood capillaries
(D) Transporting the drugs from Peyer's patches into the gut lumen.
Answer: A
Q.42 The first stage of wetting on addition of a granulating agent to the powders is
characterized by which one of the followings?
(A) Capillary state (B) Pendular state
(C) Funicular state (D) Droplet state
Answer: A
Q.43 The degree of flocculation of a suspension is 1.5 and the sedimentation volume is 0.75.
What will be the ultimate volume of deflocculated suspension?
(A) 2.0 (B) 1.5 (C) 0.75 (D) 0.5
Answer: A
Q.44 A drug is administered to a 65 Kg patient as 500 mg tablets every 4 hours. Half- life of
the drug is 3 h, volume of distribution is 2 liter/Kg and oral bioavailability of the drug is
0.85. Calculate the steady state concentration of the drug?
(A) 5.05mcg/ml (B) 4.50 mcg/ml (C) 3.53 mcg/ml (D) 3.00 mcg/ml
Answer: D
Q.45 Statement [X] : Hofmeister series grades coagulating power of electrolytes as per
their ionic size.
Statement [Y] : The relative coagulating power is given by:
[P] Al+++ > Ba++ [Q] Li- > F- [R] NH4+ > Na+ Choose the correct statement :
(A) Statement X is true but P, Q and R are false in Statement Y
(B) Statement X is false and P, Q and R are false in Statement Y
(C) Statement X is true and Q and R are false in Statement Y
(D) Statement X is false and P is false in Statement Y
Answer: D
Q.46 Larger values of Ky in the Heckel Plot indicate formation of what quality of tablets?
(A) Harder tablets (B) Softer tablets
(C) Fluffy tablets (D) Brittle tablets
Answer: A
Q.47 Which is NOT applicable to protein binding?
(A) Klotz reciprocal plot (B) Sandberg modified equation
(C) Blanchard equation (D) Detli plot
Answer: D
Q.48 According to USP, the speed regulating device of the dissolution apparatus should be
capable of maintaining the speed within limits of what % of the selected speed?
(A) 1% (B) 2% (C) 4% (D) 5%
Answer: C
Q.49 Which statement is NOT true for steam distillation?
(A) It is also called differential distillation
(B) It can be used for separation of immiscible liquids -
(C) It can be applied for volatile substances
(D) It can be used for separation of miscible liquids
Answer: D
Q.50 What is Primogel?
(A) Substituted HPMC for direct compression
(B) Modified microcrystalline cellulose for direct compression
(C) Hydro gelling polymer for gel formation
(D) Modified starch for disintegration
Answer: D
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