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5th June 2016, 03:57 PM
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| Re: Download NIPER Syllabus
As you have asked for the Medicinal Chemistry syllabus of National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, I am giving you information about it, check below for the details I Semester MC-510 Basics of Drug Action (2 credits) 1. Structure: 2D vs 3D. Structure vs. Electronic structure. Electronic structure of ketenes and its importance in reactivity. Diels-Alder reaction, Symmetry using group theory. Graph theory and 2D structure. 2. Energy: Energy concept and its importance in drug action. First, Second and Third laws of thermodynamics and the principles derived from these laws which are of significance to drug action. 3. Thermodynamics: Free energy and Relationship between thermodynamics and statistics. Importance of chemical potential in drug action. Thermodynamic cycle. Statistical thermodynamics in predicting the structure of biomolecules and their interaction with drug molecules. Macromolecular vs. micromolecular correlation using thermodynamics and statistical thermodynamics. 4. Interactions: Inter- and intramolecular interactions. Weak interactions in drug molecules. Chirality and drug action. Covalent, ion-ion, ion-dipole, Hydrogen bonding, C-H hydrogen bonding, dihydrogen bonding, Van derWaals interactions and the associated energies. 5. Receptorology: Drug-receptor interactions, Receptor theories and drug action: Occupancy ,Theory, Rate Theory, Induced Fit Theory, Macromolecular perturbation theory, Activation- Aggregation theory. Topological and stereochemical consideration. 6. Enzyme Kinetics: enzyme kinetics in drug action. Do all molecules of an enzyme have same kinetics? Mechanisms of enzyme catalysis, Electrostatic catalysis and desolvation. Covalent catalysis, Acid-base catalysis, Strain / distortion in enzyme catalysis. Coenzyme catalysis. NIPER Hyd Medicinal Chemistry Syllabus        |