Birla Institute of Technology and Science Pilani M.Pharmacy Entrance exam syllabus

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Natural Drugs , Phyto chemistry , Pharmalcognosy :
General Pharmacognosy, traditional systems of medicine, plant nomenclature & classification, macro &
micro morphology, standardization parameters; Properties, isolation techniques, tests and functions of
alkaloids, alkaloidal drugs belonging to the classes: tropane, ecgonine, quinoline, isoquinoline, indole,
purine, phenanthrine, diterpene, peptide, steroidal classes including pseudoalkaloids; Classification,
isolation techniques, test for glycosides, glycoside drugs of class: anthraquinone, cardenolide,
bufedienolide, saponins; Classification, isolation techniques, tests for volatile oils and fixed oils, volatile
oil containing drugs including acyclic, monocyclic, bicyclic and tri cyclic terpenoidal drugs, fixed oils
containing saturated, unsaturated fatty acids; Classification, isolation procedures, test for resins, drugs of
resin alcohol, acid resin and ester resin classes, classification and tests for gums, prepared gums and
naturally occurring gums.
Reference books:
Trease & Evans „Pharmacognosy‟Saunders, 15th Ed., 2002.17
Wallis T. E. „Text book of Pharmacognosy‟, 5th Ed. 1997.

Anatomy Physiology & Hygiene:
Anatomy of a generalized cell, cellular transport mechanisms, cell division, body tissue types and
functions, their properties and characteristics., Composition and functions of blood, Plasma Proteins,
RBC, WBC, platelets- anatomy & functions, hemoglobin and blood groups, blood typing, anatomy and
physiology of the heart, blood pressure, ECG and its significance, blood vessels., General aspects of
neurology, central, peripheral nervous system ( CNS and PNS), autonomic nervous system, endocrine
glands, hormones:- their functions and mechanisms of action., Anatomy of the urinary system,
mechanisms of urine production, diseases of the kidney, male, female reproductive systems and related
disorders., Organs of the respiratory system, process of respiration, diseases related to the systems.
Reference books:
Martini F H – Fundamentals of Human Anatomy & Physiology. 4th Ed, P-H International Inc.
Guyton & Hall, A Text book of Medical Physiology XI Ed., WB Saunders Co.(Indian Ed.), Elsevier
2006

Anatomy Physiology & Hygiene:
Anatomy of a generalized cell, cellular transport mechanisms, cell division, body tissue types and
functions, their properties and characteristics., Composition and functions of blood, Plasma Proteins,
RBC, WBC, platelets- anatomy & functions, hemoglobin and blood groups, blood typing, anatomy and
physiology of the heart, blood pressure, ECG and its significance, blood vessels., General aspects of
neurology, central, peripheral nervous system ( CNS and PNS), autonomic nervous system, endocrine
glands, hormones:- their functions and mechanisms of action., Anatomy of the urinary system,
mechanisms of urine production, diseases of the kidney, male, female reproductive systems and related
disorders., Organs of the respiratory system, process of respiration, diseases related to the systems.
Reference books:
Martini F H – Fundamentals of Human Anatomy & Physiology. 4th Ed, P-H International Inc.
Guyton & Hall, A Text book of Medical Physiology XI Ed., WB Saunders Co.(Indian Ed.), Elsevier
2006

Pharmaceutical and Instrumental Methods of Analysis :
IR, NMR, MASS – spectroscopic techniques, their principles, instrumentation, molecular characterization,
calibration, operation, sample preparation and interpretation of results., UV-Vis. Spectrophotometer,
spectrofluorimeter, AAS: - their principles, instrumentation, calibration, operation, sample preparation and
interpretation of results., Chromatographic Techniques – HPLC, GC, Paper, Gel electrophoresis – their
principles, instrumentation, calibration, operation, sample preparation and interpretation of results.,
Titrimetric methods – neutralization (aqueous and non-aqueous), redox, precipitation, complexometric,
iodometric and iodimetric titrations: – their principles, applications, assay techniques., Limit tests,
microbiological assay, determination of water content, methoxyl groups; T.L.C, paper and coloumn
chromatographic techniques and their applications.
Reference books:
Willard H H “Instrumental Methods of Analysis”CBS, 7th Ed. 1988.
Beckett and Stenlake J.B.
„Practical Pharmaceutical Chemistry‟ – 4th Ed. Part I & II, 1997.

Pharmacology and Toxicology :
Introduction, Scope and principles of basic pharmacology and toxicology, mechanisms of drug action,
receptors and drug action, pharmacodynamic parameters affecting drug- receptor interaction,
Pharmacokinetics and Pharmacodynamics., Cholinergic drugs, cholinergic blockers, adrenergic drugs
and their blockers, ganglionic and neuromuscular blocking agents – their mechanisms action., General
and local anesthetics, anxiolytics, sedatives and hypnotics, antipsychotics and antidepressants, narcotic
and non-narcotic drugs, NSAID‟s, CNS stimulants anti-convulsants, anti-parkinsonics agents, their
mechanisms., Cardiotonics, antianginals, antihypertensives, diuretics, anti arrhythmic, drugs for blood
disorders – their mechanisms., Principles of Chemotherapy, classification of chemotherapeutic agents,
folate antagonists, protein, cell wall synthesis inhibitiors, quinolone antibiotics, drugs for UTI, antifungal,
antiviral, antitubercular, anthelmintics, antimoebics, anti-cancer drugs.
Reference books:
Goodman & Gilman‟s “The Pharmacological Basis of Therapeutics‟ - Fundamentals, 10th Ed., McGraw
Hill, 2001.
M J Mycek et.al., Lippincott‟s Illustrated reviews – Pharmacology-Lippincott-Ramen-III Ed. 2001.
Pharmaceutical Microbiology and Biochemistry :
Introduction and classification of microbes, bacteria, virus, fungi, protozoa – physiology and cellular
function, infections and immunity, microbials in antibiotic and vaccine preparations., Nutritional
requirements and cultivation of microbes, culture media types, physical and chemical methods of
microbial control, staining techniques, sterility testing and their validation, sterilization methods and
applications., Microbial mechanisms of human pathogenicity, diseases of the skin, CNS, GIT, Respiratory
Tract, immune system disorders, antimicrobial drugs and their evaluation., Carbohydrates Lipids,
Proteins, Nucleic acids: their structures, biosynthesis, biochemical energetic functions, clinical pathology,
deficiency disorders., Enzymes and their regulation; classification, structures, kinetics, inhibition
mechanisms, applications.
Reference books:
Microbiology – An introduction – 8
th Ed. Tortora, et.al Pearson Pub., 2004.
Prescott et.al Microbiology‟ 6th Ed. McGraw Hill, 2005.
“ Lehninger Principles of Biochemistry” – David L Nelson W.H, Framan & Co, 4th Ed. 2004.
Forensic Pharmacy and Quality Control Management :
Regulatory control of manufacturing and sales of pharmaceuticals and cosmetics, Drugs & Cosmetics
Act, Medicinal and Toilet Preparations Act, Narcotics and Psychotropic Substances Act., Regulatory
control of teaching and practice of Pharmacy: Pharmacy Act, Objectionable Advertisements Act, Shops
and Establishments Act, Drug Price Control Order, Quality Assurance and Quality Audit: QC/QA
functions, GLP, Quality audit, ISO certification, Good Manufacturing Practices: All aspects of good
manufacturing practices, documentation, protocols involved, design of premises., Pharmaceutical
Management: Planning, organizing, controlling of pharmaceutical manufacturing and marketing activities.
Reference books:
B.M. Mittal – Textbook of Forensic Pharmacy Vallabh Prakashan, 10th Ed., 1999.
Khanna O.P., Industrial Engineering and Management, Dhanpat Rai Rev.Ed. 1999.
Willing, etal, Good Manufacturing Practice for Pharmacy: A plan for Total Q.C, Marcel Dekker, 5th Ed.,
2001.

Industrial And Physical Pharmacy :
Physicochemical properties of Pharmaceutical agents, Rheology, Interfacial phenomenon, Micromeretics,
Raw materials and Materials of construction of equipments., Kinetic Phenomenon, Chemical Kinetics,
Stability testing, Dissolution, Diffusion., Materials of construction, Extraction, Communition, Mixing., Heat
transfer, Distillation, Evaporation, Drying, Fluid Flow, Humidification, Dehumidification., Filtration,
Crystallization, Compression

Reference books for:
Aulton M.E – „Pharmaceutics -The Science of Dosage Form Design-Churchill Livingston, 2nd Ed. 2002 or
ELBS, I Ed.
Lachmann, L. and Others – Theory and Practice of Industrial Pharmacy Lea Feberger 3rd ed. 1986.

Pharmaceutical Formulations and Biopharmaceutics :
Preformulation studies, Physicochemical properties of drugs and their impact on design of drug delivery
systems, classification of dosage forms; Design, Preparation, Evaluation of Pharmaceutical Dosage
Forms: Tablets, Solutions, Capsules ,Micro-encapsulation techniques;, Design, Preparation and
Evaluation of Novel Drug Delivery Systems such as : Sustained Release, Controlled Release,
Transdermal and Transmucosal, Ocular., Parenteral Products: Sterilization methodology, calculations,
evaluation and preparation., Biopharmaceutics: ADME characteristics of drug and their importance in
disease conditions, Pharmacokinetic drug interactions, bio-equivalence and bio-availability studies,
Prodrugs.
Reference books:
Mittal B.M., - Text book of Pharmaceutical Formulation – Vallabh Prakashan 6th Ed. 1997.
Brahmanker et al – Biopharmaceutics and Pharmacokinetics - A Treatise, Vallabh Prakashan, 1995.
Dispensing Pharmacy :
General Dispensing Procedures, Latin terms and Abbreviations, Pharmaceutical Calculations, Posology.,
Disperse Systems: Suspensions, Emulsions, Creams: General methods of manufacturing, problems
associated with stability., Semi-solid Preparations like Ointments, Gels, Pastes, Suppositories and
Pessaries: General methods of manufacturing, problems associated with stability., Incompatibilities
involved in prescriptions and usage of additives., Containers and Closures: selection of appropriate
containers and closures, Hospital Pharmacy Practice.

Reference books:
Cooper and Gunn – Dispensing for Pharmaceutical students – CBS, 12
th ed., 1987