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  #1  
26th July 2016, 08:10 AM
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A Basement Membrane Anchors

Hello guys , I want to know What Does A Basement Membrane Anchors ? Here Would you please tell me What is the Function & Structure of Basement Membrane Anchors ?
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  #2  
26th July 2016, 08:31 AM
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Join Date: Aug 2012
Re: A Basement Membrane Anchors

Friend I would like to tell you The primary function of the basement membrane is to anchor down the epithelium to its loose connective tissue (the dermis) underneath. This is achieved by cell-matrix adhesions through substrate adhesion molecules (SAMs).

Composition :


As Seen with Electron Microscopy, the Basement Membrane is composed of two layers, the basal lamina and the underlying layer of reticular connective tissue.

The underlying connective tissue attaches to the basal lamina with collagen VII anchoring fibrils and fibrillin microfibrils.

The Two Layers Together are Collectively referred to as the basement membrane.

The Basement Membrane is organized as follows:

Epithelial/mesothelial/endothelial tissue (outer)
Basement membrane
Basal lamina
Lamina lucida
Laminin
Integrins (hold to base)
Nidogens
Dystroglycans
Lamina densa
Collagen IV (coated with perlecan, rich in heparan sulfate)
Attaching proteins (between the basal and reticular laminae)
Collagen VII (anchoring fibrils)
Fibrillin (microfibrils)
Lamina reticularis
Collagen III (as reticular fibers)
Connective tissue (inner)


Function and Importance :


• The basement membrane acts as a mechanical barrier, preventing malignant cells from invading the deeper tissues.

• Early stages of malignancy that are thus limited to the epithelial layer by the basement membrane are called carcinoma in situ.

• The basement membrane is also essential for angiogenesis (development of new blood vessels).

• Basement membrane proteins have been found to accelerate differentiation of endothelial cells.


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