Yue Wang Institute of Molecular And Cell Biology

May I know profile of the Yue Wang work at Institute of Molecular And Cell Biology?

[Raman Vij]

Yue Wang is a postdoctoral research fellow at Institute Of Molecular And Cell Biology.

He did PhD from the University of Minnesota in 1988. His current research focus is on the study of the human fungal pathogen Candida albicans. Dr Wang was awarded the President's Science Award 2012.

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Contact details:
Yue WANG
Lab Location: #6-17
email: mcbwangy@imcb.a-star.edu.sg
tel:65869521

Publications:
One-step targeted gene deletion in Candida albicans haploids
Nap1 regulates the septin ring dynamics and morphogenesis in Candida albicans.
Fungal adenylyl cyclase acts as a signal sensor and integrator and plays a central role in interaction with bacteria.
The 'obligate diploid' Candida albicans forms mating-competent haploids.
Cdc28-Cln3 regulates actin-mediated endocytosis by targeting Sla1 in different modes of fungal growth.
CDK Regulates Septin Dynamics through Cell-cycle-dependent Phosphorylation of the Nim1 Kinase Gin4.
Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans.
Candida albicans Cyr1, Cap1 and G-actin form a sensor/effector apparatus for activating cAMP synthesis in hyphal growth.
CDKs and the yeast-hyphal decision.
Ras1 and Ras2 play antagonistic roles in regulating cellular cAMP level, stationary-phase entry and stress response in Candida albicans.
The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans.
Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.
Septin ring formation separates Candida albicans hyphal development into Sec3p-independent and dependent phases.
Critical Role of DNA Checkpoints in Mediating Genotoxic-Stress-induced Filamentous Growth in Candida albicans.
The F-box protein Grr1 regulates the stability of Cln1, Cln3 and Hof1 and cell morphogenesis in Candida albicans.
RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development.
The formin family protein CaBni1p has a role in cell polarity control during both yeast and hyphal growth in Candida albicans.
Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.
CaSPA2 is important for polarity establishment and maintenance in Candida albicans.

Characterization and Functional Analysis of the Siderophore-Iron Transporter CaArn1p in Candida albicans.
The mitotic spindle checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice.

A high affinity iron permease essential for Candida albicans virulence.
Cell transformation and activation of pp60c-src by overexpression of a protein Expression and characterization of wild type, truncated, and mutant forms of the intracellular region of the receptor-like protein tyrosine phosphatase HPTPβ. J Biol The human receptor-like protein tyrosine phosphatase HPTPα has two active domains with distinct substrate specificity.

Research Topics:

Discovery of the Cdc42 GAP Rga2 as a direct substrate of CDK/Hgc1. Upon hyphal induction CDK/Hgc1 phosphorylates Rga2 and prevents this negative regulator of polarized growth from localizing to hyphal tips. This finding establishs a direct link between CDK and the central polarity regulator of the cell.

Identification of the septin Cdc11 as a regulatory target of two G1-cyclin/CDKs important for both yeast bud morphogenesis and hyphal morphogenesis. This study establishes a direct molecular link between CDK and the septin cytoskeleton.

Identification of a key regulator of hyphal development, Hgc1. This study reveals the first and so far the only hypha-specific gene required for hyphal development.

Discovery of a high-affinity iron permease, Ftr1, essential for Candida albicans virulence. The permease is activated in iron-limiting conditions both in vitro and in the tissues of the host, allowing the pathogen to acquire the growth-essential nutrient iron.

For more detail, you can contact to;
Address
Institute of Molecular and Cell Biology
61 Biopolis Dr, Singapore 138673 ‎
+65 6586 9755

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