#1
20th March 2013, 10:40 AM
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What is Epigallocatechin Gallate EGCG
What is Epigallocatechin Gallate EGCG?
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#2
20th March 2013, 02:24 PM
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Re: What is Epigallocatechin Gallate EGCG
The Epigallocatechin Gallate EGCG is the also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin. It is basically found in the green tea. The structure of EGCG can be similar to the image given below: The ECGC is used in medical applications, some of them I have given below: Therapeutic use 1.1 HIV 1.2 Cancer 1.3 Chronic fatigue syndrome 1.4 Sjögren's syndrome 1.5 Endometriosis 1.6 Spinal muscular atrophy 1.7 Neurodegeneration 1.8 Cannabinoid 1 receptor, CB1 receptor Activity 1.9 Periapical lesions |
#3
21st March 2015, 03:43 PM
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Re: What is Epigallocatechin Gallate EGCG
Please tell me that what is Epigallocatechin Gallate (EGCG)? Also give list of enzymes of Epigallocatechin Gallate?
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#4
21st March 2015, 03:43 PM
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Re: What is Epigallocatechin Gallate EGCG
Epigallocatechin gallate (EGCG) is also known as epigallocatechin-3-gallate and it is the ester of epigallocatechin and gallic acid, and is a type of catechin. EGCG is the most abundant catechin in tea and it is a polyphenol under basic research for its potential to affect human health and disease. It is found mainly in white tea, green tea and, in smaller quantities, black tea; during black tea production, the catechins are mostly converted to theaflavins and thearubigins. Pharmacology: EGCG is an inhibitor of the enzymes followings: • Histone acetyltransferase • DNA methyltransferas • Fatty acid synthase • Glutamate dehydrogenase • Topoisomerase I and II • Aromatic L-amino acid decarboxylase • 11β-Hydroxysteroid dehydrogenase Names: IUPAC name: [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl] 3,4,5-trihydroxybenzoate Preferred IUPAC name: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate Properties: Molecular formula: C22H18O11 Molar mass: 458.37 g•mol−1 Appearance: Solubility in water: soluble (33.3-100 g/L)[vague] Solubility: soluble in ethanol, DMSO, dimethyl formamide at about 20 g/l EGCG provides anti-disease effects or overall health benefits in following diseases: HIV Cancer Chronic fatigue syndrome Sjögren's syndrome Endometriosis Spinal muscular atrophy Neurodegeneration CB1 receptor activity Periapical lesion Cerebrovascular insult |