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13th August 2014, 03:04 PM
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Join Date: Apr 2013
Re: NIPER Entrance Exams Syllabus

Here I am giving you syllabus for National Institute of Pharmaceutical Education and Research (NIPER) entrance examination below :

Syllabus:
Chemistry
Amino acids proteins
Aromaticity
Carbohydrates classification
Chromatography
Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen
E and Z isomerism
Huckel’s rule reaction mechanisms-Ester hydrolysis
Hybridization
Imine-enamine
Introduction to Redox reactions
Introduction to thermal methods of analysis
IUPAC nomenclature
Keto-enol tautomerism
Medicinal chemistry and Bulk Drugs
Mutarotation
Osazone test
Pericyclic reactions
Reactions like Cannizarro’s reaction
R and S nomenclature
Racemic mixture
Reaction kinetics, first second third and pseudo first order reactions, radio labeling for determination of mechanism.
Resolution methods
Spectroscopy
Tautomerism
Various Heterocycles, Heterocycle synthesis, reactions

Natural Products
Phytochemistry
Methods of extraction, isolation and characterization of natural products
Biosynthetic pathways
Primary metabolites
Secondary metabolites
Important therapeutic classes
Dietary antioxidants
Marine natural products
Plant growth regulators
Spectroscopy
Stereochemistry

Fischer, sawhorse and newmon projection formulaes
Biological sources of important classes of natural products
Standardization of natural products

Pharmacology and toxicology
Pharmacokinetics
Pharmacodynamics
Pharmacological effect, desired, undesired, toxic, adverse effects
Bioavailability, bioequivalence, various factors of ADME
Drug metabolism
Drug interactions, agonist, antagonist, protein binding, drug distribution, distribution volume, excretion pathways
Pharmacological screening
Mechanism of drug action
Drug-receptor interaction
Various adrenergic, cholinergic and other receptors
Detailed study of CNS pharmacology
Study of basis of threshold areas of work in NIPER in pharmacology dept. mentioned in brochure.
Diseases
Chemotherapy and pathophysiology
Bioassay methods
Pharmaceutics and formulation (Pharmaceutical Technology)
Drug delivery systems (DDS)
Carriers in DDS
Transdermal drug delivery systems (TDDS)
Parenterals
Drug targeting
Complexation
Solubilization
Polymerization
Viscosity measurements
Dosage form development- stages, implications of dosage form
Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities
Dosage forms
Packaging
Compartmental modeling
Bioavailability, bioequivalence studies
Evaluation of formulation, principles and methods of release control in oral formulations

Pharmaceutical analysis
Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf life determination, thermal stability, formulation stability
Various analytical techniques
Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests.
Spectroscopic methods
Particle sizing
Electrophoresis
Chromatography- detailed
QA and QC: GLP, TQM, ISO system
Preformulation, cyclodextrin inclusion compounds
Solubility
Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties.
Dosage forms, Stages of dosage form development
Osmolality, osmolarity, osmotic pressure, conductivity, Preservatives, Media for bioassay

Biotechnology
Pharmaceutical technology

Genetic Engineering
Gene expression
Mutation
Replication
Transcription, translation
Recombination, bacteriophages

Cloning
Fermentation Methods, isolation of nucleic acids, enzymes in cloning, restriction endonucleases, DNA ligase, DNA gyrase, polymerases

Gene Therapy
Monoclonal antibodies
Insulin
Interferons
Enkephalins
Angiotensin analogues and other peptides


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