H-Clat Workshop

I missed last year work shop of Human Cell Line Activation Test (H-Clat). So please provide me last year videos of that work shop. I want to know all information about last year work shop. Is there any Work shop on Human Cell Line Activation Test (H-Clat) organize in this year?

I want to get the details of Human Cell Line Activation Test (h-CLAT) Workshop of IIVS so can you provide me?

[pawan]

The Human Cell Line Activation Test (h-CLAT) is a cell-based assay that identifies skin sensitizers by examining changes in the expression of cell surface markers implicated in dendritic cell activation, the third key event of the skin sensitization AOP.

Following exposure of the THP-1 human monocyte cell line to the test substance, expression levels of CD54 and CD86 are quantified by flow cytometry and compared to controls.

The method has been reviewed by the European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) and has been recommended as a useful tool in an integrated testing strategy for identification of skin sensitizers.

Currently, the assay has an accepted OECD guideline (OECD 442E).

IIVS offers this assay as part of an Integrated Testing Strategy for predicting skin sensitization.

Features:


Human Cell Line model

Cytotoxicity assessment included

Well-established assay that is predictive across many chemistries

Sophisticated analysis of protein expression via flow cytometry

Please contact IIVS for more information on the h-CLAT assay.

Contact-


Institute for In Vitro Sciences
30 West Watkins Mill Road
Suite 100
Gaithersburg, MD 20878

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Phone: 301-947-6523
Fax: 301-947-6538
Email: info@iivs.org